Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intellectual functions in childhood malignant disorders

B Bhattacharya1, R K Marwaha, S Malhotra

  • 1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.

Indian Pediatrics
|August 1, 1995
PubMed
Summary

Children with lymphoreticular malignancies receiving CNS-directed therapy showed slightly lower intellectual function, particularly in specific cognitive areas. Age at diagnosis significantly impacted IQ scores, but treatment type had minimal long-term effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pagetoid Squamous Cell Carcinoma In-Situ of Esophagus.

Kathmandu University medical journal (KUMJ)·2024
Same author

Efficacy and safety of various oral regimens (three oral doses) and schedules (daily <i>v</i>. monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial.

The British journal of nutrition·2022
Same author

Indian Academy of Pediatrics Revised (2021) Guidelines on Prevention and Treatment of Vitamin D Deficiency and Rickets.

Indian pediatrics·2021
Same author

Inherited Bleeding Disorders in North Indian Children: 14 years' Experience from a Tertiary Care Center.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2020
Same author

Evaluation of serum anti-nuclear antibody among women with PCOS: a hospital based single center cross sectional study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2018
Same author

Comparative cognitive effects of phenytoin and carbamazepine in adult epileptics.

Neurology India·2018

Area of Science:

  • Pediatric Oncology
  • Neuropsychology
  • Childhood Cancer Research

Background:

  • Central nervous system (CNS) directed therapy is crucial for treating certain childhood cancers but may impact cognitive development.
  • Understanding the long-term intellectual effects of different cancer treatments in children is essential for comprehensive care.

Purpose of the Study:

  • To compare intellectual functions in children with lymphoreticular malignancies (ALL or NHL) treated with CNS-directed therapy versus those with solid tumors treated with chemotherapy alone.
  • To identify factors influencing intellectual outcomes in pediatric cancer patients.

Main Methods:

  • Intellectual assessment using Malin's modification of the Wechsler's intelligence scale for Indian children.
  • Comparison of verbal IQ, performance IQ, and full scale IQ between two groups: Group A (lymphoreticular malignancies with CNS therapy) and Group B (solid tumors).

Related Experiment Videos

  • Analysis of subscale scores and influence of age at diagnosis, sex, duration since diagnosis, disease-free survival, and treatment variables.

    • Main Results:

    • Mean verbal IQ, performance IQ, and full scale IQ were comparable between the two groups, with no statistically significant differences.
    • Greater dispersion of IQ scores and a higher number of subjects with scores below 80 were observed in Group A.
    • Lower scores in arithmetic, digit-span, picture completion, and block design subscales were noted in Group A.
    • Children over 10 years at diagnosis exhibited significantly lower mean IQ scores.
    • Sex, duration since diagnosis, disease-free survival, and treatment variables did not significantly affect IQ scores.

    Conclusions:

    • Cross-sectional evaluation reveals minimal intellectual differences between children treated with chemotherapy and CNS-directed therapy versus chemotherapy alone.
    • While overall IQ scores are comparable, specific cognitive deficits and a wider range of scores may be associated with CNS-directed therapy.
    • Age at diagnosis is a significant factor influencing intellectual outcomes in pediatric cancer patients, underscoring the need for age-specific monitoring and support.