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Related Experiment Videos

Drug discrimination under a concurrent schedule

S H Snodgrass1, D E McMillan

  • 1University of Arkansas for Medical Sciences, Little Rock 72205, USA.

Journal of the Experimental Analysis of Behavior
|May 1, 1996
PubMed
Summary

Pigeons learned to distinguish pentobarbital from saline. Drug dose influenced their choices, showing graded dose-response curves for pentobarbital and chlordiazepoxide, not all-or-none effects.

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Area of Science:

  • Behavioral pharmacology
  • Neuroscience
  • Drug discrimination studies

Background:

  • Drug discrimination assays are crucial for understanding drug effects on behavior.
  • Pigeons are widely used animal models for studying drug-induced behavioral changes.

Purpose of the Study:

  • To investigate dose-dependent effects of various drugs on pigeon behavior.
  • To characterize the dose-response curves of pentobarbital, methamphetamine, phencyclidine, and chlordiazepoxide.
  • To assess the interaction between pentobarbital and a barbiturate antagonist.

Main Methods:

  • A two-key concurrent schedule of reinforcement was employed.
  • Pigeons were trained to discriminate pentobarbital (5.0 mg/kg) from saline.
  • Dose-response curves were generated for multiple drugs and drug combinations.

Main Results:

  • Pigeons dose-dependently altered their responding based on drug administration.
  • Pentobarbital and chlordiazepoxide exhibited graded dose-response relationships.
  • Methamphetamine showed flat dose-response curves, while phencyclidine produced inconsistent effects.
  • Bemegride antagonized the effects of pentobarbital, decreasing pentobarbital-appropriate responding.

Conclusions:

  • Drug discrimination in pigeons provides a graded measure of drug effects.
  • Pentobarbital and chlordiazepoxide effects are dose-dependent and graded.
  • Bemegride can attenuate pentobarbital's discriminative stimulus properties.

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