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Cisapride-induced long QT interval
M B Lewin1, R M Bryant, A L Fenrich
1Lillie Frank Abercrombie Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
The Journal of Pediatrics
|February 1, 1996
Summary
Cisapride treatment in an infant with gastroesophageal reflux caused bradycardia and a prolonged QT interval. Symptoms resolved after discontinuing cisapride, indicating a potential risk in pediatric patients.
Area of Science:
- Pediatric Cardiology
- Clinical Pharmacology
Background:
- Gastroesophageal reflux is common in infants.
- Cisapride is a medication used to treat gastrointestinal motility disorders.
Observation:
- A 2-month-old infant experienced bradycardia and a prolonged QT interval during cisapride therapy for gastroesophageal reflux.
- Electrocardiogram confirmed 2:1 atrioventricular conduction and a prolonged QT interval.
Findings:
- Discontinuation of cisapride led to the normalization of the infant's heart rhythm and QT interval.
- This suggests a causal relationship between cisapride and the observed cardiac events.
Implications:
- Healthcare providers should monitor pediatric patients for cardiac side effects, specifically prolonged QT interval, when prescribing cisapride.
- The findings highlight the importance of considering drug-induced cardiac toxicity in infants and children.