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Cisapride-induced long QT interval

M B Lewin1, R M Bryant, A L Fenrich

  • 1Lillie Frank Abercrombie Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

The Journal of Pediatrics
|February 1, 1996
PubMed

Insights

Cisapride treatment in an infant with gastroesophageal reflux caused bradycardia and a prolonged QT interval. Symptoms resolved after discontinuing cisapride, indicating a potential risk in pediatric patients.

Area of Science:

  • Pediatric Cardiology
  • Clinical Pharmacology

Background:

  • Gastroesophageal reflux is common in infants.
  • Cisapride is a medication used to treat gastrointestinal motility disorders.

Observation:

  • A 2-month-old infant experienced bradycardia and a prolonged QT interval during cisapride therapy for gastroesophageal reflux.
  • Electrocardiogram confirmed 2:1 atrioventricular conduction and a prolonged QT interval.

Findings:

  • Discontinuation of cisapride led to the normalization of the infant's heart rhythm and QT interval.
  • This suggests a causal relationship between cisapride and the observed cardiac events.

Implications:

  • Healthcare providers should monitor pediatric patients for cardiac side effects, specifically prolonged QT interval, when prescribing cisapride.
  • The findings highlight the importance of considering drug-induced cardiac toxicity in infants and children.

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