Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolones: structure-activity relationships and future predictions

G S Tillotson1

  • 1Pharmaceutical Division, Bayer plc, Strawberry Hill, Newbury, Berkshire.

Journal of Medical Microbiology
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial resistance--fluoroquinolones and the tiger's tail.

Journal of chemotherapy (Florence, Italy)·2006
Same author

Geographically-based evaluation of multidrug resistance trends among Streptococcus pneumoniae in the USA: findings of the FAST surveillance initiative (2003-2004).

International journal of antimicrobial agents·2006
Same author

Adverse cutaneous reactions and drugs: a focus on antimicrobials.

Journal of chemotherapy (Florence, Italy)·2006
Same author

Future trends in antimicrobial chemotherapy: expert opinion on the 43rd ICAAC.

Journal of chemotherapy (Florence, Italy)·2004
Same author

Antimicrobial selection for community-acquired lower respiratory tract infections in the 21st century: a review of gemifloxacin.

International journal of antimicrobial agents·2004
Same author

Respiratory fluoroquinolones: differences in the details.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2004
Same journal

Integrated clinical and genomic characterization of <i>Acinetobacter baumannii</i> causing bloodstream infections in a Chinese tertiary hospital.

Journal of medical microbiology·2026
Same journal

Rapid bacterial community profiling of equine faecal, skin, milk and saliva samples using Oxford Nanopore long-read 16S rRNA amplicon sequencing.

Journal of medical microbiology·2026
Same journal

Suggestive associations between genetically predicted gut microbiota and endometriosis: a two-sample Mendelian randomization study.

Journal of medical microbiology·2026
Same journal

Whole-genome sequencing of <i>Listeria monocytogenes</i> from maternal and neonatal clinical isolates in Kuwait.

Journal of medical microbiology·2026
Same journal

The Dynamiker cryptococcal antigen lateral flow assay is an accurate, rapid and cost effective test comparable to culture for detection of cryptococcal meningitis.

Journal of medical microbiology·2026
Same journal

R pyocin sensitivity of <i>Pseudomonas aeruginosa</i> clinical isolates from different disease types.

Journal of medical microbiology·2026
See all related articles

The development of fluoroquinolones, a significant advancement from nalidixic acid, offers broader antibacterial activity and improved dosing. These modified quinolone antibiotics show promise for enhanced therapeutic applications.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Microbiology

Background:

  • Nalidixic acid, the first clinically useful quinolone, was developed in 1962.
  • The addition of fluorine at the C6 position led to the creation of fluoroquinolones, a significant breakthrough.
  • Over 10,000 analogues of nalidixic acid and fluoroquinolones have been synthesized.

Purpose of the Study:

  • To review the core fluoroquinolone structure.
  • To examine modifications in current fluoroquinolone analogues under development.
  • To understand the impact of chemical modifications on drug-host interactions.

Main Methods:

  • Literature review of quinolone and fluoroquinolone development.
  • Analysis of chemical structures and modifications.

Related Experiment Videos

  • Discussion of pharmacokinetic and pharmacodynamic properties.

    • Main Results:

    • Fluoroquinolones offer benefits such as oral/parenteral dosing and broader antibacterial spectrum.
    • Improved tissue distribution, pharmacokinetics, and stability are key advantages.
    • These agents exhibit a comparatively low incidence of adverse effects.

    Conclusions:

    • Chemical modifications to the fluoroquinolone core enhance therapeutic potential.
    • Understanding these modifications is crucial for predicting drug interactions.
    • Fluoroquinolones represent a vital class of modern antibacterial agents.