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The war on cancer

M B Sporn1

  • 1Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA.

Lancet (London, England)
|May 18, 1996
PubMed
Summary
This summary is machine-generated.

The War on Cancer has seen successes in childhood cancers but has yet to significantly reduce adult mortality from epithelial cancers. Future progress requires focusing on metastasis, early prevention, and preneoplastic lesions.

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Area of Science:

  • Oncology
  • Cancer Research
  • Public Health

Background:

  • President Nixon initiated the "War on Cancer" 25 years ago.
  • Significant progress has been made in treating certain childhood cancers, Hodgkin's disease, and testicular cancer.

Purpose of the Study:

  • To review the progress and challenges of the "War on Cancer" over the past 25 years.
  • To identify reasons for the limited impact on adult epithelial cancer mortality.

Main Methods:

  • Personal commentary and review of historical cancer research efforts.
  • Analysis of successes and failures in cancer treatment and prevention strategies.

Main Results:

  • Triumphs include cures for acute lymphocytic leukemia, other childhood cancers, Hodgkin's disease, and testicular cancer.

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  • Advances in molecular oncology have not yet translated into reduced mortality for common adult epithelial cancers.
  • Key failures include overlooking the lethality of metastasis over proliferation, prioritizing advanced disease cure over early prevention, and neglecting preneoplastic lesion management.

    • Conclusions:

    • The "War on Cancer" has achieved notable successes but has not yet secured victory.
    • A shift in focus towards preventing early-stage disease, managing metastasis, and addressing preneoplastic lesions is crucial for future progress.