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Posttraumatic macroglossia complicated by hyaluronidase injection

J C Dort1

  • 1Department of Surgery, University of Calgary, Alberta, Canada.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 1, 1996
PubMed
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This case study presents posttraumatic macroglossia, a rare tongue swelling after injury. Hyaluronidase injection exacerbated swelling, suggesting a causal link and advising against its use for tongue injuries.

Area of Science:

  • Traumatology
  • Otolaryngology
  • Dermatology

Background:

  • Posttraumatic macroglossia is a rare condition following tongue injury.
  • It typically presents with acute onset swelling.
  • Literature review indicates limited reported cases.

Observation:

  • A patient presented with delayed onset of macroglossia after tongue injury.
  • Swelling significantly worsened after hyaluronidase injection.
  • This association has not been previously reported.

Findings:

  • A causal relationship between hyaluronidase injection and macroglossia exacerbation is suggested.
  • The drug may induce or worsen tongue swelling.
  • Delayed onset of symptoms is possible.

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Implications:

  • Hyaluronidase should not be used to treat swelling post-tongue injury.
  • Further research is needed to understand this adverse reaction.
  • Clinicians should be aware of this potential complication.