Related Experiment Videos
Alcaligenes xylosoxidans subsp xylosoxidans in children with chronic otorrhea
1College of Pharmacy, Ohio State University, Columbus 43210, USA.
Abstract:
Because other known pathogens are frequently isolated with AXX, its clinical significance may be overlooked. AXX should not be considered a colonizer or contaminant, particularly in the presence of clinical signs and symptoms of infection. For a pediatric patient with AXX in the ear fluid, the choice of an antibiotic regimen should be based on in vitro activity of both AXX and other concurrent pathogens. Although the sensitivity of AXX may be highly variable, a number of antibiotics appear to be clinically useful.
Insights
Aureus X (AXX) is a significant pathogen, not a contaminant, especially with infection symptoms. Treatment requires considering AXX and other pathogens, with several antibiotics showing clinical utility despite variable sensitivity.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Diagnostics
Background:
- Aureus X (AXX) is often found with other pathogens, potentially masking its clinical importance.
- Distinguishing AXX as a pathogen versus a colonizer is crucial for effective treatment.
Observation:
- In pediatric patients, AXX in ear fluid necessitates careful consideration.
- Concurrent isolation of other pathogens alongside AXX is common.
Findings:
- AXX should be treated as a pathogen when clinical signs of infection are present.
- Antibiotic selection must account for the in vitro activity against both AXX and co-infecting organisms.
- Despite variable sensitivity, several antibiotics demonstrate clinical usefulness against AXX.
Implications:
- Overlooking AXX can lead to delayed or inappropriate treatment.
- Tailored antibiotic regimens based on susceptibility testing are essential for pediatric ear infections involving AXX.
- Further research into AXX's variable antibiotic sensitivity is warranted.