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Related Experiment Videos

Amikacin administration in open heart surgery

O Oto1, Y Tunçok, S Apaydin

  • 1Dokuz Eylül University Hospital, Department of Pharmacology, Inciralti, Izmir, Turkey.

Panminerva Medica
|June 1, 1995
PubMed
Summary

Repeating amikacin doses after open heart surgery is unnecessary. Serum amikacin levels remain adequate four hours post-administration, even after cardiopulmonary bypass, indicating stable drug concentrations.

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Area of Science:

  • Pharmacology
  • Cardiovascular Surgery
  • Critical Care Medicine

Background:

  • Amikacin is commonly administered during open heart surgery.
  • Post-cardiopulmonary bypass (CPB), serum amikacin levels may decrease due to fluid administration.
  • This necessitates investigating the need for repeat dosing after CPB.

Purpose of the Study:

  • To evaluate the necessity of administering amikacin immediately after cardiopulmonary bypass (CPB) in open heart surgery patients.
  • To determine if serum amikacin levels fall below therapeutic concentrations after CPB.

Main Methods:

  • Ten patients undergoing open heart surgery were studied.
  • Serum amikacin levels were measured at multiple time points: pre-CPB, during CPB (30 and 60 minutes), post-CPB, and 4 hours after initial administration.

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  • Statistical analysis (ANOVA) was used to assess changes in drug levels.

    • Main Results:

    • Serum amikacin levels showed a significant decrease over time (p < 0.05).
    • However, the mean serum amikacin concentration at 4 hours post-administration was 9.80 +/- 0.96 micrograms/ml.
    • This concentration remained above established trough levels.

    Conclusions:

    • The study concludes that repeating amikacin doses at the end of open heart surgery is unnecessary.
    • Serum amikacin levels are maintained adequately for at least four hours post-administration, even with CPB.
    • Current dosing protocols may be adjusted based on these findings.