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Related Experiment Videos

Pulmonary emphysema: quantitative CT during expiration

P A Gevenois1, P De Vuyst, M Sy

  • 1Department of Radiology, Hôpital Erasme, Brussels, Belgium.

Radiology
|June 1, 1996
PubMed
Summary

Expiratory computed tomography (CT) is less accurate for quantifying pulmonary emphysema than inspiratory CT. Inspiratory CT better reflects emphysema extent, while expiratory CT may indicate air trapping.

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Quantitative Imaging

Background:

  • Pulmonary emphysema is a major component of chronic obstructive pulmonary disease (COPD).
  • Accurate quantification of emphysema extent is crucial for disease management and research.
  • Computed tomography (CT) is a key imaging modality for assessing lung structure.

Purpose of the Study:

  • To evaluate the utility of expiratory thin-section CT scans in quantifying pulmonary emphysema.
  • To compare the accuracy of expiratory CT thresholds with macroscopic and microscopic emphysema assessments.

Main Methods:

  • Eighty-nine patients underwent inspiratory and expiratory CT scans.
  • Relative lung areas with low attenuation coefficients were calculated using various thresholds.

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  • Quantitative CT measurements were correlated with macroscopic and microscopic emphysema indices from resected specimens.

    • Main Results:

    • Specific expiratory CT thresholds (-820 HU for microscopic, -910 HU for macroscopic emphysema) were identified.
    • However, an inspiratory threshold of -950 HU demonstrated superior accuracy for quantifying both macroscopic and microscopic emphysema.
    • Expiratory CT showed higher correlations for pulmonary volumes but similar correlations for diffusing capacity compared to inspiratory CT.

    Conclusions:

    • Expiratory quantitative CT is less accurate for quantifying pulmonary emphysema compared to inspiratory CT.
    • Expiratory CT findings may primarily reflect air trapping rather than the reduction in alveolar surface area characteristic of emphysema.