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In vivo He-3 MR images of guinea pig lungs
R D Black1, H L Middleton, G D Cates
1Center for in Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.
Radiology
|June 1, 1996
Abstract:
The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.