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Enhanced degradation of EGF receptors by a sorting nexin, SNX1
R C Kurten1, D L Cadena, G N Gill
1Department of Medicine, University of California, San Diego, La Jolla 92093-0650, USA.
Science (New York, N.Y.)
|May 17, 1996
Abstract:
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.