Related Experiment Videos
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP
M R Novelli1, J A Williamson, I P Tomlinson
1Cancer Genetics Laboratory, Imperial Cancer Research Fund (ICRF) Laboratories, London, UK.
Science (New York, N.Y.)
|May 24, 1996
Abstract:
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.