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Expression of BCL-2 gene product in embryonal tumors of the central nervous system
1Department of Pathology, Kitasato University School of Medicine and Kanagawa, Japan.
Background:
The expression of bcl-2 is associated with suppression of programmed cell death and prolonged cell survival. Recently, immunoreactivity to the bcl-2 gene product has been reported not only in a variety of embryonal and adult nonhematopoietic tissues, but also in neuroblastoma. However, the study of bcl-2 expression has not been performed in brain tumors.
Methods:
In this study, we examined the incidence and significance of bcl-2 expression in 25 cases of embryonal tumors of the central nervous system, including medulloblastoma, neuroblastoma, ependymoblastoma, and PNET (primitive neuroectodermal tumor), which has the possibility of neuronal differentiation.
Results:
The results demonstrated that 13 tumors (52%) positive for bcl-2 belonged to early differentiated and neuronal types, and 7 negative tumors (28.0%) mostly belonged to undifferentiated type.
Conclusions:
These results have led us to speculate on the possibility that tumor cells begin expressing bcl-2 along with their neuronal differentiation from primitive cells.
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