Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and nitrovasodilators: similarities, differences, and interactions

R A Kelly1, T W Smith

  • 1Cardiovasuclar Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

The American Journal of Cardiology
|May 30, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling.

PloS one·2022
Same author

Cytokines and cardiac hypertrophy: roles of angiotensin II and basic fibroblast growth factor.

Clinical and experimental pharmacology & physiology·2010
Same author

Gene therapy progress and prospects: therapeutic angiogenesis for ischemic cardiovascular disease.

Gene therapy·2007
Same author

In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice.

Journal of cardiovascular electrophysiology·2002
Same author

Nitric oxide and cardiac contractility in human heart failure: time for reappraisal.

Circulation·2001
Same author

Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.

Hypertension (Dallas, Tex. : 1979)·2001
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

Nitric oxide (NO), produced endogenously or exogenously, relaxes vascular smooth muscle. Coronary artery disease impairs NO production, but nitrates still dilate vessels, suggesting therapeutic potential.

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function
  • Nitric Oxide Biology

Background:

  • The endothelium acts as a semipermeable barrier and secretes vasoactive substances.
  • Endothelium-derived relaxing factor (EDRF) is nitric oxide (NO), crucial for vascular smooth muscle relaxation.
  • NO signaling involves soluble guanylate cyclase and cyclic guanosine monophosphate (cGMP).

Purpose of the Study:

  • To review the dual sources of nitric oxide (endogenous and exogenous) and their mechanisms.
  • To discuss the impact of coronary artery disease on nitric oxide production.
  • To explore the role of the nitric oxide pathway in cardiac autonomic responsiveness.

Main Methods:

  • Review of existing literature on endothelial function and nitric oxide.

Related Experiment Videos

  • Discussion of endogenous nitric oxide synthesis via nitric oxide synthases.
  • Analysis of exogenous nitric oxide administration via organic nitrates.

    • Main Results:

    • Nitric oxide is synthesized endogenously or administered exogenously via nitrates.
    • Coronary artery disease disrupts endogenous nitric oxide production.
    • Exogenous nitrates remain effective vasodilators even with impaired endogenous NO production.

    Conclusions:

    • The nitric oxide pathway is vital for vascular tone and cardiac function.
    • Therapeutic strategies involving nitric oxide are important for cardiovascular health.
    • Further research is needed on nitric oxide's role in cardiac autonomic control and disease states.