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Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells
C T Aller1, O Kucuk, G F Springer
1Department of Microbiology and Immunology, Finch University Health Science, Chicago Medical School, North Chicago, Illinois 60064, USA.
American Journal of Hematology
|May 1, 1996
Abstract:
Immunophenotyping of peripheral blood lymphocytes from six patients with B-cell chronic lymphocytic leukemia (B-CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cytometry. Lymphocytes from all patients showed strong Tn expression as compared to normal control lymphocytes. By contrast, T antigen was not expressed, The TN expression may be a useful diagnostic and prognostic marker for B-CLL.