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Related Experiment Videos

Testosterone therapy in glucocorticoid-treated men

I R Reid1, D J Wattie, M C Evans

  • 1Department of Medicine, University of Auckland (New Zealand).

Archives of Internal Medicine
|June 10, 1996
PubMed
Summary

Testosterone replacement therapy can reverse the negative effects of glucocorticoid drugs on bone density and body composition in men. This treatment improved skeletal and soft-tissue mass, counteracting drug-induced side effects.

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Area of Science:

  • Endocrinology
  • Metabolic Medicine

Background:

  • Glucocorticoid therapy, while effective, causes side effects like osteoporosis and muscle wasting.
  • Reduced testosterone levels in men on glucocorticoids may contribute to these adverse effects.

Purpose of the Study:

  • To evaluate the impact of testosterone replacement on skeletal and soft-tissue parameters in men undergoing long-term glucocorticoid treatment.

Main Methods:

  • A 12-month randomized crossover study involving 15 asthmatic men on glucocorticoids.
  • Participants received either testosterone esters (250 mg/month IM) or placebo, followed by a crossover.
  • Bone density and body composition were assessed using dual-energy x-ray absorptiometry.

Main Results:

  • Testosterone supplementation significantly increased lumbar spine bone density by 5.0% (P = .005).

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  • It reversed the gain in body fat mass and loss of lean body mass observed during the control period.
  • Testosterone treatment also decreased bone turnover indexes.

    • Conclusions:

    • Testosterone replacement therapy effectively counteracts the detrimental effects of glucocorticoids on bone and soft tissues in men.
    • This suggests testosterone is a viable therapeutic option for managing glucocorticoid-induced side effects.