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Updated: Aug 15, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Expression of bcl-2 in uveal malignant melanoma
V Jay1, Q Yi, W S Hunter
1Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Objective:
To evaluate the expression of the bcl-2 proto-oncogene in uveal malignant melanomas.
Case Material:
We studied 20 uveal malignant melanomas (19 choroidal and 1 ciliary body) by immunohistochemistry with the bcl-2 oncoprotein monoclonal antibody and the cell proliferation marker, MIB-1.
Results:
Expression of bcl-2 was found in 100% of cases and was not correlated with the histologic subtype of melanoma or the MIB-1 proliferative index. Normal choroidal melanocytes were negative for bcl-2.
Conclusion:
Our results suggest that altered expression of bcl-2 is common in uveal melanomas and is not related to histologic grade.
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