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Interferon alfa induces leukocyte capillary trapping in rat retinal microcirculation
H Nishiwaki1, Y Ogura, K Miyamoto
1Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1996
Summary
Interferon alfa increases leukocyte adherence and trapping in retinal capillaries, potentially causing microinfarction in interferon-induced retinopathy. This study investigated leukocyte dynamics in rat retinal microcirculation.
Area of Science:
- Ophthalmology
- Immunology
- Pharmacology
Background:
- Interferon alfa is a potential treatment for choroidal neovascularization.
- Retinal complications have been reported following interferon therapy.
Purpose of the Study:
- To evaluate the effects of interferon alfa on leukocyte dynamics.
- Focus on the rat retinal microcirculation.
Main Methods:
- Intravenous administration of interferon alfa in rats.
- Acridine orange digital fluorography and scanning laser ophthalmoscopy used for in vivo visualization.
- Observation of leukocyte movements in the retinal microcirculation.
Main Results:
- Leukocyte adherence to vascular walls observed after interferon alfa administration.
- Leukocyte trapping in the retinal microcirculation occurred.
- Leukocyte trapping demonstrated a dose-dependent relationship.
Conclusions:
- Interferon alfa enhances leukocyte adherence and trapping in retinal capillaries.
- Interferon alfa may activate leukocytes.
- Activated leukocytes could contribute to microinfarction in interferon-induced retinopathy.