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Molecular cloning and tissue distribution of rat peptide transporter PEPT2
1Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.
Biochimica Et Biophysica Acta
|April 26, 1996
Abstract:
A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.