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Related Experiment Videos

Endothelium and bone marrow transplantation

L Catani1, L Gugliotta, N Vianelli

  • 1Institute of Hematology L and A Seràgnoli, University of Bologna, Italy.

Bone Marrow Transplantation
|February 1, 1996
PubMed
Summary

Endothelial injury markers, thrombomodulin and P-selectin, were assessed in bone marrow transplant (BMT) patients. Elevated levels were rare, appearing only in a patient with severe, lethal thrombotic complications, suggesting infrequent endothelial damage in BMT.

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Area of Science:

  • Hematology
  • Transplantation Medicine
  • Vascular Biology

Background:

  • Thrombotic complications are a concern post-marrow transplantation.
  • Endothelial injury is implicated in the pathogenesis of these complications.
  • Plasma thrombomodulin and P-selectin are potential markers of endothelial cell injury.

Purpose of the Study:

  • To investigate plasma concentrations of thrombomodulin and P-selectin in bone marrow transplant patients.
  • To clarify the extent of endothelial involvement in thrombotic complications after BMT.
  • To assess the utility of these proteins as markers of vascular endothelial cell membrane injury.

Main Methods:

  • Plasma thrombomodulin and P-selectin levels were monitored in 25 patients without thrombotic complications.

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  • Monitoring occurred pre-transplant, on day 0, and weekly for 1 month post-transplant.
  • In three patients who developed VOD, monitoring continued until day +52.

    • Main Results:

    • Thrombomodulin and P-selectin remained in the normal range for all uncomplicated patients.
    • Two patients with reversible VOD showed normal protein levels.
    • Consistently very high protein levels were observed only in the patient with severe, lethal VOD.

    Conclusions:

    • Endothelial activation or damage is infrequent during BMT for hematological malignancies.
    • Documented endothelial injury was limited to one patient with severe thrombotic complications.
    • Thrombomodulin and P-selectin may serve as indicators in cases of significant endothelial damage post-BMT.