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[Quality assurance of bacterial incidents associated with blood transfusion]
1Etablissement de Transfusion Sanguine de l'Ouest Francilien, Versailles.
Abstract:
Transfusion associated bacterial sepsis, TABS, may be caused by-donor bacteremia,-bacteria from the donors skin,-bacteria brought by one of the persons handling the donation or the blood product, from collection and components preparation to the actual transfusion,-or bacteria introduced by a defect in one of the disposables used. Quality Assurance relies on the Good Transfusion Practices of the French Blood Agency all along the transfusion chain from the donor to the recipient. Active involvement of personnel, standardisation and controls as well as improvement of technics particularly as regarding donor selection, skin disinfection technics and collection are required. The ultimate control is hemovigilance with proper identification and investigation of all cases of TABS even with mild symptoms. Centralisation of data in the Haemovigilance scheme is a further step toward a better understanding and improvement of blood products bacterial security.
Insights
Transfusion-associated bacterial sepsis (TABS) can originate from donors, handlers, or equipment. Strict adherence to Good Transfusion Practices and robust hemovigilance are crucial for ensuring blood product safety.
Area of Science:
- Transfusion Medicine
- Infectious Disease Control
- Blood Safety
Background:
- Transfusion-associated bacterial sepsis (TABS) poses a significant risk in blood transfusions.
- Potential sources of bacterial contamination include donor bacteremia, skin flora, handling procedures, and equipment defects.
Purpose of the Study:
- To outline the multifaceted causes of bacterial contamination in blood products.
- To emphasize the critical role of quality assurance and Good Transfusion Practices in preventing TABS.
- To highlight the importance of hemovigilance in identifying and managing TABS cases.
Main Methods:
- Review of potential bacterial contamination sources throughout the transfusion chain.
- Emphasis on quality assurance protocols, including donor selection and skin disinfection.
- Description of hemovigilance systems for case identification and investigation.
Main Results:
- Bacterial contamination can occur at multiple points from donor to recipient.
- Good Transfusion Practices are essential for minimizing bacterial risks.
- Hemovigilance is vital for detecting and analyzing TABS events.
Conclusions:
- Comprehensive quality assurance and strict adherence to transfusion protocols are necessary to prevent TABS.
- Centralized hemovigilance data improves understanding and enhances bacterial security in blood products.