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Related Experiment Videos

Small-bowel resection for metastatic melanoma

I F al-Sheneber1, S H Meterissian, A Loutfi

  • 1Department of Surgery, Royal Victoria Hospital, McGill University, Montreal, Que.

Canadian Journal of Surgery. Journal Canadien De Chirurgie
|June 1, 1996
PubMed
Summary

Complete resection of small-bowel metastases from melanoma significantly improves patient survival. Patients undergoing complete removal of metastatic melanoma in the small intestine had a 36% long-term survival rate.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Melanoma Research

Background:

  • Metastatic melanoma frequently spreads to the small bowel.
  • Surgical intervention for small-bowel metastases is complex.
  • Limited data exists on the survival impact of complete resection.

Purpose of the Study:

  • To evaluate the efficacy of complete resection of small-bowel metastases from melanoma.
  • To determine if surgical removal improves patient survival outcomes.

Main Methods:

  • Retrospective chart review of 20 patients with melanoma metastatic to the small bowel.
  • Analysis of surgical interventions: complete resection, partial resection, or palliative bypass.
  • Correlation of survival with extent of resection, operative morbidity, and mortality.

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Main Results:

  • Complete resection was performed in 11 patients, partial resection in 8, and palliative bypass in 1.
  • Long-term survival (2-10 years) was 36% following complete resection versus 0% after partial resection.
  • Overall operative morbidity was 20% and mortality was 15%.

Conclusions:

  • Complete surgical resection of small-bowel melanoma metastases offers a potential for long-term patient survival.
  • Aggressive surgical management may be beneficial for select patients with metastatic melanoma.