FISH studies on the Y chromosome in male urinary cells

To ascertain the meaning of the loss of the Y (-Y) in bladder cancer, we addressed the incidence of -Y in urinary cells in relation to age in 35 men without bladder cancer. Aside from the bone marrow and blood, -Y has not been examined critically in other tissues and organs in a large series of men. The present study clearly demonstrated that -Y in the group studied was an infrequent finding and not related to age.