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Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
S Haldar1, J Chintapalli, C M Croce
1Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
Cancer Research
|March 15, 1996
Abstract:
Treatment of prostate cancer cell lines expressing bcl-2 with taxol induces bcl-2 phosphorylation and programmed cell death, whereas treatment of bcl-2-negative prostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to bax since less bax was observed in immunocomplex with bcl-2 in taxol-treated cancer cells. These findings support the use of the anticancer drug taxol for the treatment of bcl-2-positive prostate cancers and other bcl-2-positive malignancies, such as follicular lymphoma.