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Ordering of the human regulator of complement activation gene cluster on 1q32 by two-colour FISH
F Pardo-Manuel de Villena1, D Heine-Suñer, S Rodriguez de Cordoba
1Departamento de Immunologia, Centro de Investigaciones Biologicas (CSIC), Madrid, Spain.
Cytogenetics and Cell Genetics
|January 1, 1996
Abstract:
The regulator of complement activation (RCA) gene cluster and PTPRC and REN genes have been mapped to the 1q31-->q32 band interval. We have used two-colour in situ hybridization to determine the chromosomal position of these genes. We report here that HF1/F13B are proximal to the C4BP/MCP genes. We also propose that PTPRC and REN genes map to a region of the RCA gene cluster between the HF1/F13B and C4BP/MCP regions. In summary, we propose the following gene order: centromere-HF1/F13B-PTPRC-REN-C4BP/MCP-telomere.