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Updated: Aug 8, 2026

In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
Published on: March 21, 2017
Memory complaints associated with the use of gonadotropin-releasing hormone agonists: a preliminary study
1Department of Psychology, University Hospital, London, Ontario, Canada.
Objectives:
To study the effect of GnRH agonist (GnRH-a) treatment on memory and to assess the role of psychological factors.
Design:
A randomized prospective study.
Setting:
An academic teaching hospital.
Participants:
Women with endometriosis and infertility or endometriosis alone.
Main Outcome Measures:
Memory Observation Questionnaire, Profile of Mood States, Health Concerns scale, a weekly diary of adverse effects.
Results:
Perceived memory functioning decreased during GnRH-a administration and by the final week of treatment 44% of women reported moderate to marked impairment in comparison to community norms. Prospective memory was most affected and withdrawal of GnRH-a treatment resulted in a return to normal memory functioning. Impairment was not related to excessive health concerns or mood changes and was uncorrelated with other adverse effects.
Conclusions:
Memory disruption may be a more common side effect of GnRH-a treatment than currently is recognized. Problems were temporary and more likely a result of rapid estrogen depletion than a consequence of mood, somatic distress, or personality factors.
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