Neurological signs, age, and illness duration in schizophrenia

Although increased prevalence of neurological signs in schizophrenia may reflect the presence of subtle brain dysfunctions, it is not clear whether there is progressive deterioration in such neurological function as the illness advances. This study compared neurological signs in patients with different durations of illness, controlling for age and education level. No deterioration in neurological signs as a function of illness duration was observed. Although there was an increase in neurological signs with age, there was a parallel increase in a control group. In addition, no change in the profile of subgroups of neurological signs was detected. These data provide further evidence for the stability of neurological dysfunction in schizophrenia. The findings are discussed in the context of the developmental origin of neurological dysfunction in schizophrenia.