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[Association of Epstein-Barr virus with primary malignant lymphomas of the digestive tract]
N Futamura1, S Nakamura, T Koshikawa
1First Department of Surgery, Gifu University School of Medicine, Japan.
Abstract:
The association of Epstein-Barr virus (EBV) with 85 non-Hodgkin lymphomas of the digestive tract in nonimmunocompromised cases was investigated, using in situ hybridization technique to detect EBV encoded small RNAs in paraffin sections. 85 cases (83 B-cell type and 2 T-cell type) included 3 gingivas, 1 tongue, 3 palates, 10 tonsils, 43 stomachs, 2 jejunums, 12 ileums, 3 ileo-cecal regions, 5 colons and 3 rectums. Out of 85 cases, 4 (4.7%) were EBV-positive, comprising 1 B-cell lymphoma of the tonsil, 2 B-cell lymphomas of the stomach, and 1 T-cell lymphoma of the rectum. On the other hand, EBV-positive rate in nasal/nasopharyngeal lymphomas examined for comparison was very high, 81.8% (9 out of 11). These results show that EBV is associated with only a small proportion of lymphomas of the digestive tract in nonimmunocompromised case, suggesting the existence of the other oncogenetic factors in the pathogenesis of this group of lymphomas.
Insights
Epstein-Barr virus (EBV) is rarely linked to digestive tract lymphomas in non-immunocompromised individuals. This suggests other factors are key in developing these cancers.
Area of Science:
- Oncology
- Virology
- Gastroenterology
Context:
- Non-Hodgkin lymphomas (NHL) are a diverse group of cancers.
- Epstein-Barr virus (EBV) is a known oncogenic virus implicated in various lymphomas.
- The role of EBV in digestive tract lymphomas, particularly in non-immunocompromised patients, requires further elucidation.
Purpose:
- To investigate the association between Epstein-Barr virus (EBV) and non-Hodgkin lymphomas (NHL) of the digestive tract in non-immunocompromised individuals.
- To determine the prevalence of EBV in these specific lymphoma cases using in situ hybridization.
Summary:
- A study examined 85 non-Hodgkin lymphomas of the digestive tract in non-immunocompromised patients for Epstein-Barr virus (EBV) using in situ hybridization.
- Only 4.7% of these digestive tract lymphomas were found to be EBV-positive.
- In contrast, EBV was detected in 81.8% of nasal/nasopharyngeal lymphomas examined for comparison.
Impact:
- The findings indicate a limited association between EBV and digestive tract lymphomas in non-immunocompromised cases.
- This suggests that other oncogenetic factors likely play a significant role in the pathogenesis of these lymphomas.
- Highlights the need for research into alternative etiological mechanisms for digestive tract lymphomas.