Related Experiment Video
Updated: Aug 8, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Orbital lesions in the blue rubber bleb nevus syndrome
C A McCannel1, J Hoenig, J Umlas
1Department of Ophthalmology, University of Colorado Health Science Center, Denver CO 80262, USA.
Purpose:
To identify ophthalmologic manifestations of the blue rubber bleb nevus syndrome, a rare cutaneovisceral hemangiomatosis.
Methods:
The authors report two patients with a diagnosis of blue rubber bleb nevus syndrome with orbital hemangiomas.
Results:
In one patient, the orbital lesion presented with signs and symptoms similar to an orbital varix and in the other with lid ecchymosis from an eyelid lesion.
Conclusion:
Patients with the blue rubber bleb nevus syndrome may have vascular orbital lesions associated with intermittent proptosis. Ophthalmologists should be familiar with the syndrome and its life-threatening complication of gastrointestinal hemorrhage.

