Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trabeculectomy with intraoperative sponge 5-fluorouracil

J S Mora1, N Nguyen, A G Iwach

  • 1Glaucoma Research and Education group, San Francisco, CA USA.

Ophthalmology
|June 1, 1996
PubMed
Summary

Intraoperative 5-fluorouracil (5-FU) sponge effectively lowers intraocular pressure after trabeculectomy surgery. This glaucoma treatment reduced medication needs and showed good safety, making it a viable option for patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of a single pain coping skills session (Empowered Relief) for outpatient postpartum pain following cesarean delivery: a pilot feasibility study.

International journal of obstetric anesthesia·2026
Same author

It's time to improve antithrombotic therapy! A global perspective for antithrombotic stewardship.

European journal of internal medicine·2026
Same author

Clinical trial and real-world evidence of circulating tumor DNA monitoring to predict recurrence in patients with resected colorectal cancer.

ESMO real world data and digital oncology·2026
Same author

A novel approach to design compact, wideband, and high-gain circularly polarized MIMO antenna using dual-polarized elements and hybrid couplers.

Scientific reports·2025
Same author

Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture.

Adipocyte·2025
Same author

Microbubble entrainment on thin liquid films under drop impacts.

Journal of colloid and interface science·2024

Area of Science:

  • Ophthalmology
  • Surgical Innovation

Background:

  • Glaucoma management often requires surgical intervention to reduce intraocular pressure (IOP).
  • Trabeculectomy is a common surgical procedure for glaucoma, but its success can be enhanced with adjunct therapies.
  • 5-fluorouracil (5-FU) is a chemotherapeutic agent used to modulate wound healing and prevent scarring in ocular surgery.

Purpose of the Study:

  • To evaluate the efficacy and safety of using intraoperative 5-fluorouracil (5-FU) sponge during trabeculectomy.
  • To assess the impact of 5-FU on intraocular pressure reduction and the need for postoperative glaucoma medications.

Main Methods:

  • A retrospective analysis of 140 eyes from 119 patients who underwent trabeculectomy with intraoperative 5-FU sponge.
  • Data collected included preoperative and postoperative intraocular pressure (IOP), number of supplementary injections, and complications.

Related Experiment Videos

  • Patients were categorized into low- and high-risk groups to assess differences in outcomes.

    • Main Results:

    • Mean preoperative IOP of 25.7 mmHg decreased to 12.5 mmHg postoperatively, a 52% reduction (P < 0.0001).
    • 86.4% of eyes achieved target IOP without postoperative glaucoma medications; mean medication use dropped significantly (P < 0.001).
    • Corneal epithelial damage occurred in 37% of eyes, correlating with postoperative 5-FU supplementation.

    Conclusions:

    • Intraoperative 5-FU sponge is a safe and effective adjunct to trabeculectomy.
    • The procedure significantly reduces IOP and the need for glaucoma medications.
    • While generally safe, potential complications like corneal damage warrant consideration, especially with supplementary 5-FU use.