[Sensitivity to acetylsalicylic acid]

Because of its ability of prevent platelet aggregation, the use of aspirin in Norway is rising abruptly, after some years of fairly low consumption. The author reviews of aspirin-sensitivity, including chronic rhinosinusitis, nasal polyposis and corticosteroid-dependent asthma. Non-steroidal anti-inflammatory drugs have widespread cross-reactions with aspirin, while azo-dyes and food preservatives may induce a similar chronic inflammation of the airways. Why some people develop aspirin-sensitivity is unknown. The basic biochemical mechanisms of aspirin-sensitivity are discussed. Specific treatment based on desensitisation and development of leukotriene receptor antagonists may be rewarding in the future. Possible beneficial or adverse effects of life-long, low-dose use of aspirin on aspirin-sensitivity should be monitored.