Related Experiment Videos
Reverse use dependence of human ventricular repolarization by chronic oral sotalol in monophasic action potential
W Shimizu1, T Kurita, K Suyama
1Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan.
The American Journal of Cardiology
|May 1, 1996
Abstract:
Reverse use dependence of action potential duration and effective refractory period by chronic oral sotalol was demonstrated by monophasic action potential recordings in the human ventricle. There were no changes of the QRS duration over the cycle length, indicating that sotalol had no sodium channel blocking effects.