Serum nifedipine concentrations and response of patients with pulmonary hypertension
B G Phillips1, J L Bauman, M D Schoen
1Department of Pharmacy Practice, University of Illinois, Chicago 60612 USA.
Abstract:
In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.
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