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E-selectin is present in proliferating endothelial cells in human hemangiomas
B M Kräling1, M J Razon, L M Boon
1Surgical Research Laboratory, Children's Hospital, Boston, Massachusetts 02115, USA.
The American Journal of Pathology
|April 1, 1996
Summary
E-selectin, an endothelial cell adhesion molecule, plays a role in angiogenesis. This study found high E-selectin expression in proliferating hemangiomas, suggesting it marks growing blood vessels.
Area of Science:
- Vascular Biology
- Oncology
Background:
- E-selectin is an endothelial cell adhesion molecule.
- Its potential role in angiogenesis, the formation of new blood vessels, is under investigation.
Purpose of the Study:
- To investigate the role of E-selectin in a noninflammatory angiogenic disease, specifically hemangiomas.
- To determine if E-selectin expression correlates with angiogenesis in hemangiomas.
Main Methods:
- Immunohistochemistry was used to analyze E-selectin expression in hemangioma specimens.
- Specimens from both the proliferative and involutive phases of hemangiomas were examined.
- E-selectin expression was also analyzed in placenta and neonatal foreskin tissues.
Main Results:
- E-selectin expression was significantly higher in the proliferative phase of hemangiomas compared to the involutive phase.
- E-selectin was co-localized with dividing microvascular endothelial cells in hemangiomas, placenta, and neonatal foreskin.
- E-selectin was not detected in quiescent endothelium.
Conclusions:
- E-selectin expression correlates with angiogenesis in hemangiomas.
- E-selectin may function in angiogenesis and could serve as a marker for proliferating endothelium.