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[Sensitivity of Yersinia pseudotuberculosis to pefloxacin]
Abstract:
Pefloxacin susceptibility of 27 Yersinia pseudo-tuberculosis isolates from the infected humans and animals (serovars 1a and 1b with different plasmid spectra) was studied by the method of two-fold serial dilutions in the liquid medium. The culture was incubated at a temperature of 37 degrees C for 48 hours. It was shown that all the isolates were highly susceptible to the antibiotic. The MIC was 0.0625-1.0 microgram/ml and did not depend on the source of the strain isolation.
Insights
All 27 Yersinia pseudo-tuberculosis isolates from humans and animals showed high susceptibility to pefloxacin. Minimum Inhibitory Concentrations (MICs) ranged from 0.0625-1.0 microgram/ml, indicating consistent effectiveness across diverse strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Yersinia pseudo-tuberculosis infections pose a zoonotic risk.
- Understanding antibiotic susceptibility is crucial for effective treatment.
- Pefloxacin is a fluoroquinolone antibiotic.
Purpose:
- To determine the pefloxacin susceptibility of Yersinia pseudo-tuberculosis isolates.
- To investigate if plasmid profiles influence antibiotic resistance.
- To establish the Minimum Inhibitory Concentration (MIC) range.
Summary:
- Twenty-seven Yersinia pseudo-tuberculosis isolates (serovars 1a and 1b) from human and animal sources were tested.
- Susceptibility was assessed using two-fold serial dilutions in liquid media at 37°C for 48 hours.
- All isolates demonstrated high susceptibility to pefloxacin, with MICs between 0.0625-1.0 µg/ml, irrespective of isolation source or plasmid profile.
Impact:
- Pefloxacin appears to be a potentially effective treatment option for Yersinia pseudo-tuberculosis infections.
- The consistent susceptibility suggests a low likelihood of pefloxacin resistance developing in these strains.
- Results aid in guiding antimicrobial therapy decisions for yersiniosis.