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Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1)

E Wey1, B W Schäfer

  • 1Division of Clinical Chemistry, Department of Pediatrics, University of Zürich, Switzerland.

Biochemical and Biophysical Research Communications
|March 18, 1996
PubMed

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
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