Synthesis and in vitro antitumor activity evaluation of 9-substituted 1,2,3,4-tetrahydrocarbazoles
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S Grasso1, C Molica, A M Monforte
1Dipartimento Farmaco-Chimico - Università di Messina, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|April 1, 1996
Abstract:
A series of 9-acetamido-1,2,3,4-tetrahydrocarbazoles (2) and 9-(aminoalkyloxyethyl)-1,2,3,4-tetrahydrocarbazoles (4) were prepared and tested for their in vitro antitumor activity. Compounds 4 are highly cytotoxic in almost all subpanel cell lines when tested at 10(-4) M, but showed a weak activity at the lowest concentrations employed.