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Pattern electroretinogram and computerized optic nerve-head analysis in ocular hypertension--interim results after
German Journal of Ophthalmology
|January 1, 1996
Summary
Pattern electroretinogram (PERG) and optic nerve head analysis (ONHA) did not predict glaucoma development in ocular hypertensive patients over a 14-month follow-up. These methods also showed disagreement in assessing glaucoma risk during this early stage.
Area of Science:
- Ophthalmology
- Neuroscience
- Clinical Medicine
Background:
- Ocular hypertension is a risk factor for glaucoma.
- Pattern electroretinogram (PERG) assesses ganglion-cell function.
- Optic nerve head analysis (ONHA) evaluates optic disc morphology.
Purpose of the Study:
- To evaluate the suitability of PERG and ONHA for detecting incipient glaucoma damage.
- To assess the predictive value of PERG and ONHA for subsequent glaucomatous visual field defects.
Main Methods:
- Prospective longitudinal study from November 1991.
- Inclusion criteria: intraocular pressure >= 25 mmHg (or >= 23 mmHg with risk factors), normal Octopus visual field, no definite glaucomatous disc cupping.
- Follow-up period: mean 14.6 months (range 1-33 months).
Main Results:
- None of the 66 patients (115 eyes) converted to glaucoma during the study period.
- PERG and ONHA showed disagreement in their estimation of glaucoma risk at this stage.
- Mean follow-up: 14.6 months; Mean intraocular pressure: 24.4 mmHg.
Conclusions:
- PERG and ONHA did not predict glaucoma development in this cohort of ocular hypertensive individuals.
- The study suggests that PERG and ONHA may not be reliable for detecting incipient glaucoma damage in the early stages.
- Further research is needed to determine the long-term predictive value and agreement between PERG and ONHA in glaucoma risk assessment.