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Resectability and survival in retroperitoneal sarcomas
C P Karakousis1, A F Velez, R Gerstenbluth
1Millard Fillmore Hospitals, Buffalo 14209, USA.
Annals of Surgical Oncology
|March 1, 1996
Summary
Wide resection significantly improves survival rates for retroperitoneal sarcomas. This approach offers better outcomes than local excision for these challenging tumors.
Area of Science:
- Surgical Oncology
- Sarcoma Research
- Oncology
Background:
- Retroperitoneal sarcomas pose management challenges due to high unresectability rates.
- Unresectability significantly impacts patient survival in retroperitoneal sarcoma cases.
Purpose of the Study:
- To evaluate the impact of surgical resection strategies on survival and recurrence rates in patients with retroperitoneal sarcomas.
- To compare the outcomes of wide resection versus local excision for retroperitoneal sarcomas.
Main Methods:
- Retrospective review of 87 consecutive patients with retroperitoneal sarcomas treated between 1977 and 1994.
- Analysis of resectability rates, survival rates (5- and 10-year), local recurrence rates, and disease-free survival based on surgical approach.
Main Results:
- Achieved 100% resectability for primary tumors and 87% for recurrent tumors.
- Wide resection demonstrated significantly lower local recurrence rates (15%) compared to local excision (56%).
- 10-year disease-free survival was substantially higher with wide resection (59%) versus local excision (7%).
Conclusions:
- Wide resection is associated with significantly higher survival rates for retroperitoneal sarcomas compared to local excision.
- Histologic grade influences survival rates for primary retroperitoneal tumors.
- Surgical strategy, particularly wide resection, is crucial for improving outcomes in retroperitoneal sarcoma management.