Related Experiment Videos
Sex chromosome abnormalities in lung cancer patients
B J Dave1, V L Hopwood, M R Spitz
1Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Genetics and Cytogenetics
|March 1, 1996
Abstract:
Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.