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t(1;19)(q23;p13) in a case of acute monocytic leukemia
H J Weh1, P Jonveaux, D Seeger
1Department of Oncology and Hematology, Medical University Clinic, Hamburg, Germany.
Cancer Genetics and Cytogenetics
|March 1, 1996
Abstract:
Translocation (1;19)(q23;p13) is considered a specific chromosome aberration in acute lymphoblastic leukemia (ALL). We report a case of M5 acute nonlymphocytic leukemia (ANLL) with t(1;19). In all mitoses studied from peripheral blood (PB) cells, the pathological karyotype 51,XX,t(1;19)(q23;p13),+8, +der(19)t(1;19)(q23;p13), +3mar was detected. No rearrangement of the E2A gene was detected. We believe this case shows that cytogenetically indistinguishable aberrations may be accompanied by quite different molecular events.