t(4;19)(q35;q13.1): a recurrent change in primitive mesenchymal tumors?
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Updated: Oct 23, 2026

Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
K E Richkind1, S G Romansky, J Z Finklestein
1Integrated Genetics, Santa Fe, NM 87505, USA.
Abstract:
We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.
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