Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Xenotransplantation]

D J White1, R Y Calne

  • 1Department of Surgery, University of Cambridge, Grossbritannien.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Xenotransplantation research addresses organ shortages by overcoming immune barriers in pig-to-human transplants. Transgenic pig technology and perfusion studies show promise for successful xenografting, advancing regenerative medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the Branching Fraction Ratios R(D^{+}) and R(D^{*+}) Using Muonic τ Decays.

Physical review letters·2025
Same author

Observation of Exotic J/ψϕ Resonant Structure in Diffractive Processes in Proton-Proton Collisions.

Physical review letters·2025
Same author

Observation of New Charmonium or Charmoniumlike States in B^{+}→D^{*±}D^{∓}K^{+} Decays.

Physical review letters·2024
Same author

Search for Time-Dependent CP Violation in D^{0}→π^{+}π^{-}π^{0} Decays.

Physical review letters·2024
Same author

Modification of χ_{c1}(3872) and ψ(2S) Production in pPb Collisions at sqrt[s_{NN}]=8.16  TeV.

Physical review letters·2024
Same author

Amplitude Analysis of the B^{0}→K^{*0}μ^{+}μ^{-} Decay.

Physical review letters·2024
Same journal

[S3 Guideline "Adult soft tissue sarcomas"].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Synopsis-S3 guidelines pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Laparoscopic sentinel node navigation surgery in gastric cancer to reduce surgical radicality].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Future concepts for neoadjuvant and adjuvant treatment of (resectable) pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[ASCO guidelines for the treatment of stage III NSCLC part 4: indications for adjuvant therapy].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Surgical treatment of pancreatic cancer-What is new?]

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
See all related articles

Area of Science:

  • Immunology
  • Transplantation Biology
  • Genetic Engineering

Background:

  • Significant organ donor shortages necessitate alternative solutions like xenotransplantation.
  • Pig-to-human xenografting faces major physiological and immunological hurdles, including hyperacute rejection.

Purpose of the Study:

  • To outline the rationale for xenotransplantation.
  • To detail strategies for overcoming immunological barriers in xenografting.
  • To present the technology for creating genetically modified pigs for transplantation.

Main Methods:

  • Review of scientific literature on xenotransplantation barriers and solutions.
  • Description of genetic modification techniques for producing transgenic pigs.
  • Analysis of perfusion studies using transgenic pig hearts and human blood.

Related Experiment Videos

Main Results:

  • Identification of key immunological challenges, particularly hyperacute rejection.
  • Development of strategies to mitigate immune responses against xenografts.
  • Perfusion data indicates successful integration and function of transgenic pig hearts with human blood, validating the approach.

Conclusions:

  • Xenotransplantation, specifically from pigs to humans, is a viable strategy to address organ scarcity.
  • Advanced genetic engineering and immunological interventions are crucial for successful xenografting.
  • Transgenic pig models show significant potential for overcoming rejection and enabling clinical application.