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Effect of octreotide on anal pressure and rectal compliance
O O Rasmussen1, C R Hansen, B W Zhu
1Department of Surgical Gastroenterology D, Herlev Hospital, University of Copenhagen, Denmark.
Purpose:
The somatostatin analog, octreotide, has previously been found to influence rectal sensation and may also influence anal resting pressure.
Methods:
We studied the effect of octreotide on anal resting pressure and rectal compliance in eight healthy patients. Octreotide was administered intravenously as a bolus injection in doses of 100 and 10 micrograms or as infusion of 250 micrograms/hour on separate days and compared with placebo.
Results:
Within one minute after a bolus injection of 100 micrograms of octreotide, anal resting pressure increased from 56 +/- 12 to 96 +/- 16 cm H2O (P < 0.005). Octrotide had no effect on rectal sensitivity or compliance measurements. Octreotide counteracted rectoanal reflex by increasing anal pressure almost to the level found with an empty rectum.
Conclusion:
Somatostatin thus seems to contribute to the regulation of rectoanal reflex.