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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jun 11, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Allergy prevention--an attainable objective?

D W Hide1

  • 1Clinical Allergy Research Unit, St Mary's Hospital NHS Trust, Newport, Isle of Wight, England.

European Journal of Clinical Nutrition
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Allergy rates are rising, but prevention strategies may need to start before birth. New research suggests immune responses develop in utero, challenging traditional primary allergy prevention methods.

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Last Updated: Jun 11, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Immunology
  • Allergy Research
  • Preventive Medicine

Background:

  • Significant increase in immunoglobulin E (IgE) mediated diseases globally.
  • Genetic and environmental factors contribute to allergy development.
  • Traditional allergy prevention is categorized as primary, secondary, or tertiary.

Purpose of the Study:

  • To investigate the timing of sensitization in allergic diseases.
  • To evaluate the effectiveness of current allergy prevention strategies.
  • To explore the concept of intrauterine programming in allergy.

Main Methods:

  • Review of recent studies on infant immune responses.
  • Analysis of peripheral blood mononuclear cell proliferative responses in infants.
  • Examination of interferon-gamma (IFN-γ) levels in cord blood.

Main Results:

  • Evidence suggests immune responses and sensitization can occur before birth (intrauterine programming).
  • Infants from atopic families show altered immune responses at birth.
  • Reduced IFN-γ in cord blood of infants from atopic families indicates early immune changes.

Conclusions:

  • Current primary allergy prevention (preventing sensitization) may be too late.
  • Intervention may need to occur during pregnancy or even pre-conception.
  • Rethinking allergy prevention is crucial due to in utero immune development.