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Behavior therapy: endogenous serotonin therapy?

L Baer1

  • 1Department of Psychology, Harvard Medical School, Cambridge, Mass., USA.

The Journal of Clinical Psychiatry
|January 1, 1996
PubMed
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Behavior therapy, including exposure and ritual prevention, effectively treats obsessive-compulsive disorder (OCD) and panic disorder. This approach, potentially influencing serotonin levels, is being made more accessible through telephone-based methods.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Therapy

Background:

  • Behavior therapy, particularly exposure and ritual prevention (ERP), is a proven treatment for obsessive-compulsive disorder (OCD) and panic disorder, often used with pharmacotherapy.
  • While serotonin's role in conditioning is suggested by animal studies, its reciprocal effect by conditioning processes remains largely unexplored.
  • Neuroimaging studies indicate that successful ERP and serotonin reuptake inhibitor (SRI) pharmacotherapy normalize brain glucose metabolism in OCD patients.

Purpose of the Study:

  • To explore the potential impact of conditioning and reconditioning on serotonin levels.
  • To investigate the link between behavioral interventions and neurobiological changes in OCD.
  • To introduce an innovative, automated telephone-based system for delivering behavior therapy.

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Main Methods:

  • Review of controlled trials on behavior therapy (ERP) and pharmacotherapy for OCD and panic disorder.
  • Analysis of existing animal and human neuroimaging research on serotonin, conditioning, and treatment effects.
  • Description of a novel automated telephone delivery system for behavior therapy.

Main Results:

  • Behavior therapy (ERP), alone or with medication, is highly effective for OCD and panic disorder.
  • Indirect evidence suggests conditioning may influence serotonin, supported by normalized glucose metabolism in treated OCD patients.
  • A new automated telephone system aims to increase access to behavior therapy.

Conclusions:

  • Behavior therapy shows significant efficacy in treating OCD and panic disorder, potentially through mechanisms affecting serotonin.
  • Further research is warranted to elucidate the conditioning-serotonin interaction.
  • Automated telephone delivery offers a promising avenue to broaden access to effective behavioral treatments.