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Cimetidine therapy for warts: a placebo-controlled, double-blind study
E Yilmaz1, E Alpsoy, E Basaran
1Department of Dermatology, Akdeniz University Medical Faculty, Antalya, Turkey.
Journal of the American Academy of Dermatology
|June 1, 1996
Summary
Cimetidine, an H2-receptor antagonist, was investigated for its effectiveness in treating warts. This study found that cimetidine is no more effective than a placebo for common wart treatment.
Area of Science:
- Dermatology
- Immunology
Background:
- Cimetidine, an H2-receptor antagonist, exhibits immunomodulatory effects.
- Previous studies suggested potential efficacy of cimetidine in treating viral skin conditions like warts.
Purpose of the Study:
- To evaluate the effectiveness of cimetidine in treating common warts through a placebo-controlled trial.
Main Methods:
- A double-blind, placebo-controlled study involving 70 patients with multiple warts.
- Participants received either cimetidine (25-40 mg/kg daily) or placebo for 3 months.
- Monthly examinations were conducted to assess treatment outcomes.
Main Results:
- Cure rates were 32% for the cimetidine group (9/28) and 30.7% for the placebo group (8/26).
- No statistically significant difference in efficacy was observed between cimetidine and placebo (p = 0.85).
Conclusions:
- Cimetidine demonstrated no superior efficacy compared to placebo in the treatment of common warts.
- Further research may be needed to explore alternative therapeutic strategies for warts.