Renal ischemia and contrast urography

Exposure to urographic contrast material, meglumine diatrizoate, in a previously ischemic kidney was investigated for its effect on renal function. Eleven mongrel dogs, 19.8-32.7 kg in weight, having the left kidney ischemic for 90 minutes were given either 4 cc/kg meglumine diatrizoate or control, Ringer's lactate solution. The effect on creatinine clearance of the left kidney was determined acutely and at 72 hours. Statistical analysis of the data reveals no deleterious effect from exposure to meglumine diatrizoate over and above the effect of the ischemic episode. There was no statistically significant effect on recovery of renal function in this animal model.