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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

49
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
49
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

40
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Related Experiment Video

Updated: May 3, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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Increased intestinal permeability in bronchial asthma

A Benard1, P Desreumeaux, D Huglo

  • 1Service de Pneumologie et Immuno-allergologle, Hôpital A. Calmette, Lille, France.

The Journal of Allergy and Clinical Immunology
|June 1, 1996
PubMed
Summary

Patients with asthma exhibit increased intestinal permeability, suggesting a potential systemic mucosal defect. This finding was consistent across allergic and non-allergic asthma, regardless of disease severity or treatment.

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Murine Model of Allergen Induced Asthma
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Related Experiment Videos

Last Updated: May 3, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Murine Model of Allergen Induced Asthma
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Area of Science:

  • Immunology
  • Gastroenterology
  • Pulmonology

Background:

  • T lymphocytes are key in asthma's bronchial inflammation.
  • Lymphocytes can migrate between mucosal sites.
  • This study investigates digestive barrier abnormalities in asthma.

Purpose of the Study:

  • To demonstrate mucosal abnormalities in the digestive barrier of asthma patients.
  • To assess intestinal permeability in individuals with asthma.

Main Methods:

  • Prospective study involving 37 asthma patients (21 allergic, 16 non-allergic).
  • Measured intestinal permeability using chromium 51-labeled ethylenediaminetetraacetatic acid (CrEDTA) urinary recovery.
  • Compared results with 13 COPD patients and 26 healthy controls.

Main Results:

  • Asthma patients showed significantly higher CrEDTA urinary recovery (2.5%) compared to COPD (1.16%) and healthy controls (1.36%).
  • No significant difference in intestinal permeability between allergic and non-allergic asthma.
  • Intestinal permeability was not correlated with asthma severity (FEV1), Aas score, steroid treatment, serum IgE, or eosinophil count.

Conclusions:

  • Results support a hypothesis of a generalized mucosal system defect in asthma, either as a cause or consequence.
  • This defect may involve the digestive barrier in individuals with asthma.