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Mantle-cell lymphoma: a population-based clinical study

G A Velders¹, J C Kluin-Nelemans, C J De Boer

¹Department of Hematology, Leiden University Hospital, Leiden, The Netherlands.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|April 1, 1996

Summary

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Mantle cell lymphoma (MCL) affects the elderly with widespread disease and poor treatment response. Despite indolent features, MCL acts aggressively, leading to short survival times.

Area of Science:

Hematology
Oncology
Clinical Research

Background:

Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL).
Understanding MCL's incidence and clinical behavior is crucial for patient management.

Purpose of the Study:

To analyze the incidence and behavior of MCL.
To compare MCL with other low- or intermediate-grade NHL subtypes.
To identify prognostic factors in MCL patients.

Main Methods:

Population-based registry analysis of 41 MCL patients.
Comparison with other NHL subtypes.
Assessment of clinical parameters, cyclin D1, and Ki-67 expression.

Main Results:

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MCL constituted 3.7% of NHL cases, predominantly in elderly males (median age 68).
Most patients presented with advanced stage (IV) disease and bone marrow involvement.
Complete response rate was 32%, with a median overall survival of 31.5 months. Low Ki-67 (<10%) correlated with better survival.

Conclusions:

MCL is a disease of the elderly with advanced presentation and poor therapeutic outcomes.
Clinically, MCL behaves aggressively despite some indolent NHL features.
Proliferative index (Ki-67) is a significant prognostic indicator for overall survival in MCL.